Figure 1 | Scientific Reports

Figure 1

From: Novel PI3K/AKT targeting anti-angiogenic activities of 4-vinylphenol, a new therapeutic potential of a well-known styrene metabolite

Figure 1

(A) Chemical structure of 4-vinylphenol (4VP). (B) HPLC chromatograms of 4VP and HD aqueous extract. (C) HD aqueous extract inhibited cell proliferation, tube formation, migration and motility in HUVEC in a concentration-dependent manner. Results are expressed as the mean + SD of 3–4 independent experiments. (D) HD aqueous extract inhibited subintestinal vessel formation in zebrafish embryos. Results are expressed as the mean + SEM (n = 30–40) of 3 independent experiments. Differences between the treated and untreated control groups were determined by one-way ANOVA with Tukey’s post-hoc test. *p < 0.05, **p < 0.01, ***p < 0.005 as compared among groups.

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