Figure 1 | Scientific Reports

Figure 1

From: Temporal MRI characterization, neurobiochemical and neurobehavioral changes in a mouse repetitive concussive head injury model

Figure 1

Altered brain morphology in repetitive closed-head injury (rCHI).

(A) Representative ADC maps of repeated closed head injury (rCHI) at 1, 7 and 30 days of recovery. Top row shows a representative T2 weighted anatomical scan. From top to bottom are the sham condition and 1, 7 and 30 days post injury. Scale bar on the right indicates image threshold for voxel diffusion values are between 0 and 0.002 mm2/sec. (B) Histograms showing the distribution of whole brain voxel ADC (upper) and T2 (lower) values for sham mice and mice sustaining rCHI. Mice were imaged following 1, 7 and 30 days of recovery from initial trauma to the head. Data are expressed as % total brain voxels (± SEM) for several ADC or T2 values. Arrows (upper panel) highlight histogram shifting in rCHI animals from low ADC on day 1 to average values on day 30. Circles (lower panel) also highlight differences between rCHI and other conditions. (C) ADC and T2 (upper and lower respectively) values for frontal cortex (FCTX), hippocampus (HIPP) and sensorimotor cortex (SCCTX) for various TBI conditions. Data are expressed as mean ADC or T2 values (± SEM). *Significantly different from sham condition; **significantly different from 1 day recovery condition (MANOVA with Sidak’s multiple comparison post-hoc test, p <0.05).

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