Figure 6 | Scientific Reports

Figure 6

From: Folic acid inhibits COLO-205 colon cancer cell proliferation through activating the FRα/c-SRC/ERK1/2/NFκB/TP53 pathway: in vitro and in vivo studies

Figure 6

Effect of FA on tumor growth and survival rate in tumor bearing mice.

(A) FA dose-dependently reduces the growth rate of tumors in SCID mice. Gross appearance of subcutaneous tumors after treatment with FA or vehicle for 48 days. The upper panels show that FA treatment causes a decrease in the level of VWF protein and increases in the levels of CDKN1A, CDKN1B and TP53 protein. The gels have been run in the same experimental conditions and the cropped blots were shown. The entire gel pictures of Fig. 6A were shown in the Supplemental Figure 4C. (B) Average tumor volume of vehicle-treated (diamond) vs. FA-treated (square, 100 μg FA; triangle, 300 μg FA). FA dose-dependently reduces the tumor volume. (C) FA dose-dependently prolongs the lifespan of mice bearing the COLO-205 tumor. Co, control; VWF, Von Willebrand factor.

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