Figure 3

Protective efficacy of H7N9/AAca in mice.

Groups of eight mice were challenged with 10⁵ EID₅₀ of rAH/1 three weeks after being inoculated with one dose (A and B) or two doses (C and D) of H7N9/AAca. Three mice were killed on day 3 post-challenge and their organs were collected for virus titration (A and C); the remaining five mice were observed for weight changes for 14 days (B and D). a, P < 0.05 compared with the corresponding value for PBS (mock)-inoculated animals.