Figure 5
From: Mannan-modified adenovirus targeting TERT and VEGFR-2: A universal tumour vaccine
Effect of the combined vaccine on the infiltration of T-cells in tumour tissues.
Cell suspensions were prepared from tumour tissues of mice immunized over four cycles with PBS (A), Adv (B), Adv-m (C), AdVEGFR2-m (D), AdTERT-m (E) or Ad(VEGFR2:TERT)-m (F). After incubation with mAb to CD4 and CD8, the suspension was subjected to flow cytometry. The ratio of CD8+ T cells in the combined vaccine group (F) was markedly higher than that observed in the controls (A-E), as shown in the bar graph (G) (*p < 0.05, variance test).
