Figure 1
Endogenous conversion of omega-6 to omega-3 fatty acids reduces metabolic endotoxemia and systemic low grade inflammation.
C57BL/6 male WT (n = 10) and fat-1 transgenic mice (n = 10) were maintained on the same diet high in n-6 PUFA since weaning for 8 months. A group of age-matched male WT mice fed with a chow diet (n = 10) was used as control. Blood samples were collected from all the mice at the same time and subjected to various analyses. (a) Parameters of metabolic endotoxemia (LPS, LBP and sCD14); (b) Serum levels of inflammation-related cytokines (TNF-α, IL-1β, IL-6 and IL-10) and (c) Markers of metabolic syndrome (body weight, fasting blood glucose, fasting insulin and HOMA-IR). Data are expressed as mean ± SE. Data with different superscript letters are significantly different (P < 0.05) according to one-way ANOVA with Tukey test.
