Figure 8
Diagram illustrating a proposed mechanism by which elevated tissue n-3 PUFA status and a reduced tissue n-6/n-3 fatty acid ratio up-regulate endogenous IAP activity in the gut, decreasing LPS-producing bacteria (e.g. E. coli) while increasing LPS-suppressing bacteria (e.g. Bifidobacterium). These changes lower LPS production and gut permeability, resulting in reduced metabolic endotoxemia. The subsequent reduction of inflammatory cytokines leads to the suppression of chronic low-grade inflammation and metabolic syndrome.
