Figure 4 | Scientific Reports

Figure 4

From: Radiation quality-dependence of bystander effect in unirradiated fibroblasts is associated with TGF-β1-Smad2 pathway and miR-21 in irradiated keratinocytes

Figure 4

miR-21 played an important role in bystander micronucleus formation in WS1 cells co-cultured with α-irradiated HaCaT cells.

Panel a, the alterations of miR-21 of HaCaT cells after α- and X-irradiation. Panel b, overexpression of miR-21 in HaCaT cells 24 and 72 h after miR-21 mimic transfection. Panel c, the effect of overexpression of miR-21 in HaCaT cells by miR-21 mimic transfection on the bystander micronucleus formation in unirradiated WS1 cells. Panel d, downregulation of miR-21 in HaCaT cells 24 and 72 h after miR-21 inhibitor transfection. Panel e, downregulation of miR-21 in HaCaT cells alone induced bystander-like effect in WS1 cells after co-culture. * P < 0.05, **P < 0.01 and *** P < 0.001 compared with the relative control.

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