Figure 3
The rTV-Fluc infection of Rag2-/- rats resulted in less weight gain and pathological tissue injuries.
(a) The body weights of SD and Rag2-/- rats infected with rTV-Fluc via ID or IV routes were recorded (n = 3). Histopathological analysis of lung (b), spleen (c), kidney (d), heart (e), ovary (f), brain (g) and muscle (h) at day 35 post infection of IV 2 × 107 pfu of rTV-Fluc. Paraffin fixed tissue sections were stained with haematoxylin and eosin and arrows indicated lesion sites. Scale bar, 20–100 μm. The bioluminescent imaging of each organ is displayed on the upper right, with colors ranging from 1e4 p/sec/cm2/sr to 1e5 p/sec/cm2/sr.
