Figure 10 | Scientific Reports

Figure 10

From: Surface chemistry but not aspect ratio mediates the biological toxicity of gold nanorods in vitro and in vivo

Figure 10

Biotoxicity and biodistribution of CTAB/PAH-coated GNRs in vivo.

Twelve 6-week-old male BALB/c mice were used to study the toxicity of CTAB/PAH-coated GNRs (a–c). (a) The body weights were measured every 2 days. MDA assay of (b) liver tissues and (c) blood samples treated with vehicle or with CTAB/PAH-coated GNRs in mice. (d) Blood samples from the mice were subjected to serum ALT activity analysis. (e) Biodistribution of CTAB/PAH-coated GNRs in mice for 4 h and 24 h after intravenous injection. Inductively coupled plasma mass spectrometry (ICP-MS) was employed to measure the total amount of gold in the heart, liver, spleen, lungs, kidneys and tumor tissue. The data are described as the mean values and standard deviations (n = 3).

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