Figure 1

Effects of combined mutations K153D, S223N and G272S in H5-HA of A/Thailand/KAN-1/2004 (KAN-1) on the informational spectra (IS).

a) IS of HA1 of the wildtype KAN-1 virus, b) IS of HA1 from the KAN-1 virus-derived triple mutant. Frequencies at 0.076 and 0.236 for avian and human receptor specificity are indicated.