Figure 6
Ab initio modelling of a mature TTR protofibril.
The filtered average model of the protofibril is shown in three views where the model is rotated 90° around its long axis and 90° to show the top view. The model has a length of 65 nm and a diameter of 13 nm. The surface representation of the TTR tetramer (1TTA.pdb) is shown at scale with the fibril. The approximate dimension of the native tetrameric TTR is 7 × 5 × 4 nm. All images are visualised using PyMol. The PyMOL Molecular Graphics System, Version 1.5.0.4 Schrödinger, LLC.
