Table 2 Selection analysis of the S gene of OC43 genotypes.

From: Genetic drift of human coronavirus OC43 spike gene during adaptive evolution

Genotype

Mean dN/dSa

Siteb

amino acid

dN/dS ± S.E.c

Prd (ω >1)

Subunit/Domaine

B

0.29

131

T

2.27 ± 1.50

0.658

NTD

  

192

L

1.93 ± 1.58

0.536

NTD

  

263

S

2.28 ± 1.50

0.663

NTD

  

421

G

2.28 ± 1.50

0.648

RBD

  

627

I

2.11 ± 1.55

0.603

S1

  

951

Q

2.41 ± 1.51

0.710

S2

C

0.20

1001

T

2.43 ± 1.42

0.768

S2

D

0.31

33

N

6.15 ± 1.78

0.94

NTD

  

38

P

5.56 ± 2.35

0.836

NTD

  

90

K

5.94 ± 2.04

0.902

NTD

  

93

T

5.90 ± 2.08

0.895

NTD

  

115

T

3.72 ± 3.11

0.535

NTD

  

120

D

6.17 ± 1.76

0.943

NTD

  

176

Y

3.85 ± 3.11

0.556

NTD

  

184

K

6.35 ± 1.50

0.976

NTD

  

195

L

3.80 ± 3.11

0.548

NTD

  

265

L

5.45 ± 2.42

0.818

NTD

  

266

D

4.93 ± 2.66

0.731

NTD

  

267

I

5.08 ± 2.60

0.755

NTD

  

354

S

3.95 ± 3.10

0.572

RBD

  

395

I

5.81 ± 2.16

0.878

RBD

  

521

Y

6.47 ± 1.27

0.999

RBD

  

535

F

5.32 ± 2.49

0.796

RBD

  

716

Q

3.61 ± 3.11

0.518

S2

  

741

Q

3.61 ± 3.11

0.517

S2

  

763

R

6.47 ± 1.26

1.000

S2

  

768

G

4.77 ± 2.78

0.706

S2

  

782

V

6.38 ± 1.45

0.982

S2

  

813

S

3.59 ± 3.11

0.515

S2

  

989

L

5.67 ± 2.34

0.855

S2

  

1255

D

4.97 ± 2.64

0.737

S2

  

1310

C

3.87 ± 3.11

0.559

S2

E

0.15

NA

NA

NA

NA

 
  1. adN/dS, the ratio of nonsynonymous (dN) to synonymous;
  2. bThe amino acid positions of genotype B were determined according to 87309 Belgium 2003 (AY903459) and 5240/07 (KF572844) for genotype C and D;
  3. cS.E. Standard error;
  4. dPr, probability;
  5. eNTD, N-terminal domain; RBD, receptor-binding domain; S, spike gene.
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