Figure 1
Ghrelin-agonist-treated animals performed better in a water maze test.
They showed a faster learningcurve than did the group fed a high-GI diet alone. Intra-day differences between high-GI and high-GI + ghrelin agonist groups were significant for day 3 ((a), one-way ANOVA followed by post-hoc Tukey’s multiple comparisons test, p = 0.026), an Area-Under-The-Curve (AUC)-comparison for the graphs in (a) revealed that ghrelin agonist treated animals showed a strong tendency to perform better over the entire experiment ((c), p = 0.061, one-way ANOVA/Tukey’s). During probe trials (time to first entry in the correct quadrant), the difference between high-GI and high-GI + ghrelin agonist were significant at tendency level only ((b), p = 0.096 for high GI vs. high GI + ghrelin agonist, p = 0.054 for high GI + ghrelin agonist vs. controls, one-way ANOVA/Tukey’s). Bars indicate SEM.
