Figure 1
From: XI-006 induces potent p53-independent apoptosis in Ewing sarcoma
MDM4 protein is overexpressed in sarcomas
a) Representative images of sarcoma MDM4 immunohistochemical staining. MDM4 grading determined from the average number of MDM4 positive cells from four fields of view, Grade 0 (<10% positive cells), Grade I (11–25% positive cells), Grade II (26–50% positive cells), Grade III (>51% positive cells) Scale bar=100uM. (b) Correlation between sarcoma pathology and percentage positive MDM4 cells determined from immunohistochemical analysis. Asterisk denotes statistical significance in MDM4 expression (****P < 0.0001). (c) Lack of correlation between MDM4 SNP34091 genotype (AA, AC, CC) and percentage positive MDM4 cells determined from immunohistochemical analysis.
