Table 2 XI-006 IC50 values of the sarcoma cell line cohort.
From: XI-006 induces potent p53-independent apoptosis in Ewing sarcoma
Cell line | Histology | TP53 status | MDM4 mRNA expression | XI-006 IC50 (nM, 24 hr) | XI-006 IC50 (nM, 48 hr) |
|---|---|---|---|---|---|
STA-ET-1 | ES | Wild-type | 1.68 ± 0.03 | 376.3 ± 26.9 | 98.9 ± 19.5 |
TC252 | ES | Wild-type | 2.74 ± 0.04 | 390.2 ± 106.6 | 115.6 ± 6.6 |
SK-N-MC | ES | Truncation | 0.61 ± 0.00 | 472.3 ± 176.4 | 121.8 ± 31.7 |
SK-ES-1 | ES | Cys176Phe | 0.70 ± 0.01 | 442.4 ± 57.5 | 236.0 ± 15.0 |
RD-ES | ES | Arg273Cys | 0.32 ± 0.00 | 638.9 ± 142.4 | 299.7 ± 68.5 |
TC71 | ES | Truncation | 0.40 ± 0.02 | 567.9 ± 150.8 | 396.1 ± 78.8 |
WE-68 | ES | Wild-type | 1.09 ± 0.04 | 2089.3 ± 20.4 | 1475.7 ± 222.6 |
VH-64 | ES | Wild-type | 1.07 ± 0.01 | 2456.4 ± 315.1 | 1613.1 ± 274.4 |
Saos-2 | OS | Null | 0.17 ± 0.00 | 3600.2 ± 525.7 | 2143.0 ± 34.9 |
SJSA | OS | Wild-type | 0.15 ± 0.01 | 6257.1 ± 366.5 | 3690.5 ± 270.2 |
U20S | OS | Wild-type | 1.94 ± 0.04 | >10 000 | 5416.8 ± 255.7 |
IMR90 | LFB | Wild-type | — | 8348.0 ± 231.0 | 6802.1 ± 696.5 |
