Figure 5
From: Integrative miRNA and Gene Expression Profiling Analysis of Human Quiescent Hepatic Stellate Cells
In vitro modulation of miRNA-21, miRNA-100 and miRNA-192 expression in LX2 cells.
Reduction of miR-21 and miR-100 expression and up-regulation of miR-192 in LX2 cells was achieved by transfecting miR-21 antagomir (50 nM), miR-100 antagomir (50 nM) or miR-192 mimic (50 nM), respectively (n = 3). (A) Box plots show the significant negative correlation between miRNA and target gene expressions. MiR-21 and miR-100 inhibition causes an increase of the expression levels of their target genes while miR-192 overexpression decreases target gene expression levels (B) In vitro modulation of miR-21, miR-100 and miR-192 expression result in a reduction of HSC activation.
