Figure 5 | Scientific Reports

Figure 5

From: Amniotic fluid stem cells provide considerable advantages in epidermal regeneration: B7H4 creates a moderate inflammation microenvironment to promote wound repair

Figure 5

hAFS cells indirectly promote wound healing in vivo

(a) Real-time PCR analysis of mRNA expression of repair-related factors (bFGF, VEGF, TGF-β1, KGF, CXCL12 and CXCR4) at days 7, 14, 21 in hAFS cell-treated wounds, the fibroblast group and a sham control group. (b) Real-time PCR analysis of mRNA expression of inflammatory factors (TNF-α, Cox2, Mac3, IL-6, IL-1β) at days 1, 4, 7, 14 and 21 in hAFS cell-treated wounds in the fibroblast and sham control groups. Both mouse and human sequences were quantified in each case. There was no expression of human bFGF, VEGF, CXCL12, TGF-β1, KGF, TNF-α, Cox2, Mac3, IL-6, or IL-1β in either hAFS-, fibroblast- or sham-treated wounds. The data are presented as the mean ± SD of three independent experiments. Analysis was performed with GraphPad Prism; *p < 0.05.

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