Figure 2 | Scientific Reports

Figure 2

From: Structural and Physical Basis for Anti-IgE Therapy

Figure 2

Conformational changes in the IgE-Fc upon binding its receptors.

Top: The Cε3 domains adopt a closed conformation when bound to CD23 (PDB 4gko), an open one when bound to FcεRI (PDB 1f6a) and a hybrid conformation with chain A “open” and chain B “closed” when IgE is free in solution (PDB 2wqr). Bottom: The Cε2 domains adopt a bent conformation with contacts to one of the Cε3-4 domains in free IgE (PDB 2wqr), becomes even more bent upon binding FcεRI (PDB 2y2q), but is extended when bound to two non-omalizumab anti-IgE molecules (PDB 4j4p).

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