Figure 1
From: MiR-19a regulates PTEN expression to mediate glycogen synthesis in hepatocytes
MiR-19a is down-regulated in the livers of db/db mice and mice injected with IL-6 as well as mouse NCTC 1469 hepatocytes and HEP 1-6 hepatocytes treated with IL-6.
(a) Reduced miR-19a expression in the livers of db/db mice, as verified by real-time PCR. (b–g) MiR-19a expression in the mouse NCTC 1469 hepatocytes and HEP 1–6 hepatocytes treated with 33.3 mM glucose for 48 h (b and c), 10 ng/ml hIL-6 for 24 h (d and e) and 10 ng/ml TNF-α for 24 h (f and g). (h) Expression of miR-19a in the livers of 12-week-old male C57BL/6J mice injected with 16 μg/ml IL-6 by pumps for 7 days. Data represent the mean ± S.D. N = 3 independent experiments or N = 5 mice.*p < 0.05; **p < 0.01 by ANOVAtest (vs. control).
