Table 4 The oral single-dose of SNs treated to rats for analysis in vivo.

From: Chemical and Metabolic Profiling of Si-Ni Decoction Analogous Formulae by High performance Liquid Chromatography-Mass Spectrometry

Si-Ni Decoction Analogous Formulae

Daily Dosagea (g/kg)

Oral Single-doseb (g/kg)

SIN

7.2

57.3

RSIN

8.6

68.5

TSIN

9.7

77.8

ZSIN

10.6

85.0

FSIN

7.1

56.7

  1. aDaily dosage means the dosage for per kilogram body weight rat every day. It was translated from a human equivalent dose taking into account body weight and body surface area.
  2. bOral single-dose is the actual dosage in our animal experiment. Based on the maximal oral dosage and the solubility of SNs, the oral single-dose of SNs was 3.2 mL per 100 g body weight (i.e. 8 times daily dosage).
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