Table 3 Meta-analysis of the MMP3 gene -1171 5A/6A polymorphism (rs35068180) on periodontitis risk.

From: Matrix Metalloproteinase-3 -1171 5A/6A Polymorphism (rs35068180) is Associated with Risk of Periodontitis

Variables

N (Case/Control)

6A allele vs. 5A allele

5A/6A vs. 5A/5A

6A/6A vs.5A/5A

5A/6A + 6A/6A vs.5A/5A

6A/6A vs. 5A/5A + 5A/6A

OR (95% CI)

Phet, I2 (%)

OR (95% CI)

Phet, I2 (%)

OR (95% CI)

Phet, I2 (%)

OR (95% CI)

Phet, I2 (%)

OR (95% CI)

Phet, I2 (%)

All

7 (1213/1831)

0.70 (0.62, 0.80)

0.315, 15.0

0.50 (0.39, 0.65)

0.221, 31.9

0.42 (0.25, 0.69)

0.265, 24.4

0.49 (0.38, 0.62)

0.238, 29.1

0.74 (0.53, 1.02)

0.539, 0.0

HWE

4 (721/946)

0.80 (0.67, 0.96)

0.655, 0.0

1.58 (0.40, 6.22)

1.30 (0.34, 4.94)

1.37 (0.36, 5.20)

0.85 (0.54, 1.33)

Type of periodontitis

 CP

7 (1004/1831)

0.72 (0.63, 0.82)

0.163, 34.8

0.50 (0.39, 0.64)

0.345, 9.6

0.41 (0.25, 0.68)

0.336, 11.3

0.48 (0.38, 0.62)

0.317, 14.9

0.77 (0.56, 1.07)

0.438, 0.0

 AgP (Asian)

2 (209/445)

0.66 (0.48, 0.91)

0.945, 0.0

4.09 (0.21, 80.21)

1.84 (0.10, 35.43)

2.44 (0.13, 46.28)

0.49 (0.24, 1.04)

Ethnicity

 Asian

4 (963/1227)

0.68 (0.58, 0.80)

0.149, 43.7

0.52 (0.40, 0.68)

0.198, 38.2

0.45 (0.25, 0.81)

0.173, 42.9

0.51 (0.39, 0.66)

0.202, 37.4

0.71 (0.49, 1.03)

0.357, 2.9

 Asian&CP

4 (754/1227)

0.73 (0.55, 0.96)

0.052, 61.2

0.52 (0.40, 0.68)

0.333, 9.0

0.44 (0.24, 0.79)

0.226, 32.8

0.50 (0.39, 0.65)

0.284, 20.6

0.75 (0.52, 1.10)

0.260, 25.7

 Caucasian (CP)

1 (67/202)

0.66 (0.44, 0.97)

 

 

 Brazilian Mixed (CP)

2 (183/402)

0.80 (0.62, 1.04)

0.477, 0.0

0.31 (0.13, 0.77)

0.32 (0.12, 0.89)

0.31 (0.13, 0.76)

0.83 (0.42, 1.64)

Smoke

 Non-smokers

3 (612/495)

0.73 (0.60, 0.88)

0.414, 0.0

0.54 (0.39, 0.75)

0.151, 47.1

0.50 (0.28, 0.89)

0.260, 25.8

0.53 (0.39, 0.73)

0.189, 40.0

0.80 (0.57, 1.13)

0.825, 0.0

  1. N, Number of comparisons; OR, odds ratio; 95% CI, 95% confidence interval; CP, chronic periodontitis; AgP, aggressive periodontitis.