Table 2 Association of HMGA2 and MIF expression levels (immunohistochemical scores of three proteins increased in the OSCC tumors) with clinicopathological characteristics in 215 untreated OSCC patients.

From: Low-molecular-mass secretome profiling identifies HMGA2 and MIF as prognostic biomarkers for oral cavity squamous cell carcinoma

No.

HMGA2

MIF

Immunohistochemical score*

p-value

Immunohistochemical score*

p-value

Gender

Female

24

43 ± 51.301 (180, 0)

0.800

152 ± 44.026 (220, 50)

0.821

Male

191

47 ± 62.124 (270, 0)

 

153 ± 44.926 (230, 40)

 

Age †

<49.8

106

44 ± 56.491 (230, 12.5)

0.848

155 ± 41.605 (220, 50)

0.899

>49.8

109

49 ± 65.104 (270, 10)

 

152 ± 47.758 (230, 40)

 

pT Status

1–2

110

36 ± 53.253 (250, 10)

0.036

139 ± 48.589 (220, 40)

<0.001

3–4

105

58 ± 66.483 (270, 40)

 

169 ± 33.743 (230, 90)

 

pN Status

(–)

137

34 ± 53.053 (230, 10)

<0.001

145 ± 45.294 (220, 50)

<0.001

( + )

78

67 ± 68.126 (270, 50)

 

168 ± 39.750 (230, 40)

 

Overall Pathological Stage

I-II

79

29 ± 45.033 (170, 10)

0.003

133 ± 48.298 (220, 50)

<0.001

III-IV

136

57 ± 66.520 (270, 35)

 

165 ± 37.701 (230, 40)

 

Cell differentiation ††

W-D  + M-D

188

40 ± 54.131 (250, 10)

<0.001

152 ± 44.667 (230, 40)

0.078

P-D

26

98 ± 81.471 (270, 100)

 

168 ± 41.668 (220, 50)

 

Perineural Invsion

No

147

37 ± 56.375 (260, 10)

<0.001

144 ± 46.012 (220, 40)

<0.001

Yes

68

67 ± 65.548 (270, 50)

 

173 ± 34.264 (230, 50)

 

Tumor depth†,††

<=8

107

35 ± 56.832 (250, 0)

<0.001

139 ± 46.230 (220, 50)

<0.001

>8

107

58 ± 63.078 (270, 40)

 

169 ± 37.274 (230, 40)

 
  1. W-D: well-differentiated, M-D: moderatively-differentiated, and P-D: poorly-differentiated, squamous cell carcinoma.
  2. *Mean ± SD, median (maximum, minimum).
  3. †Median,
  4. ††data absent in one patient.
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