Figure 6 | Scientific Reports

Figure 6

From: Bridging Links between Long Noncoding RNA HOTAIR and HPV Oncoprotein E7 in Cervical Cancer Pathogenesis

Figure 6

HOTAIR interacts with HPV16 oncoprotein E7.

(a) catRAPID fragments based prediction of interaction between HOTAIR and HPV16 E7 and maps HOTAIR interaction domains to nts 1–770 (5′-end) and nts 1700–2370 (3′-end). (b,c) catRAPID graphic output confirming the interaction of HPV16 E7 to the 5′ and 3′ ends of HOTAIR transcript as predicted by catRAPID fragments. (d) qRT-PCR results shows HOTAIR is significantly enriched with the SUZ12 antibody compared to IgG (control antibody) in untransfected C33A cells while a significant enrichment of HOTAIR was found both for HPV16 E7 and SUZ12 antibody in HPV16 E7 expressing C33A cells although lower for SUZ12.

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