Table 1 Pharmacokinetic parameters of digoxin in mice.

From: Inhibition of P-glycoprotein Gene Expression and Function Enhances Triptolide-induced Hepatotoxicity in Mice

Parameters

Digoxin+NC-siRNA

Digoxin+mdr1a-siRNA

t1/2 (h)

5.7 ± 1.3

4.0 ± 1.4

Cmax (ng/ml)

1737.8 ± 573.7

2255.4 ± 266.9

AUC(0-t) (ng·h/ml)

3363.3 ± 739.1

8774.0 ± 1448.7##

CL (ml/min/kg)

252.8 ± 62.9

99.8 ± 22.7##

Vd (L/kg)

2.0 ± 0.5

0.6 ± 0.08###

MRT (h)

3.7 ± 0.3

3.8 ± 0.4

  1. Data are presented as mean ± SD (n = 5). ##P < 0.01, ###P < 0.001, compared with NC-siRNA group.
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