Table 2 Toxicokinetic parameters of triptolide in mice.

From: Inhibition of P-glycoprotein Gene Expression and Function Enhances Triptolide-induced Hepatotoxicity in Mice

Parameters

TP+NC-siRNA

TP+Tariquidar

TP+mdr1a-siRNA

t1/2 (h)

0.34 ± 0.14

0.49 ± 0.22

0.49 ± 0.23

Cmax (ng/ml)

413.1 ± 74.2

471.6 ± 66.5

509.7 ± 94.1#

AUC(0-t) (ng·h/ml)

103.5 ± 9.6

145.9 ± 24.6#

154.3 ± 30.2#

CL (ml/min/kg)

9564.0 ± 1024.2

6576.4 ± 1438.5#

5755.4 ± 1200.1#

Vd (L/kg)

4.8 ± 1.1

3.9 ± 1.3

3.3 ± 0.7#

MRT (h)

0.34 ± 0.13

0.50 ± 0.22

0.51 ± 0.23

  1. Data are presented as mean ± SD (n = 5). #P < 0.05, compared with NC-siRNA group.
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