Table 3 Hepatic concentrations of triptolide in mice.

From: Inhibition of P-glycoprotein Gene Expression and Function Enhances Triptolide-induced Hepatotoxicity in Mice

TP (ng/g protein)

5 min

30 min

60 min

120 min

TP+NC-siRNA

1953.3 ± 786.7

394.9 ± 41.2

170.6 ± 66.3

37.4 ± 12.2

TP+Tariquidar

2857.3 ± 909.4

683.9 ± 61.3#

302.8 ± 22.7#

36.1 ± 14.4

TP+mdr1a-siRNA

4278.0 ± 653.1#

950.8 ± 232.1#

326.2 ± 22.4#

84.8 ± 14.5#

  1. Data are presented as mean ± SD (n = 5). #P < 0.05, compared with NC-siRNA group.
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