Figure 7
From: RalB regulates contractility-driven cancer dissemination upon TGFβ stimulation via the RhoGEF GEF-H1
Model outlining the role of RalB/Exocyst pathway in the dissemination of TGFβ-treated A549 cells.
TGFβ-treated cells generate traction forces which are required to remodel the extracellular matrix and to disseminate in 2/3D environment. This requires the activation of the Rho/ROCK pathway and actomyosin function. The Ral pathway controls the dissemination of TGFβ-treated cells by modulating RhoA-dependent actomyosin contractility via the interaction between the Sec5 subunit of Exocyst and the RhoGEF GEF-H1.
