Table 1 Parameter estimated by mathematical-experimental analysis.
From: Quantifying the Antiviral Effect of IFN on HIV-1 Replication in Cell Culture
Parameter Name | Symbol | Unit | aHIV-1 NL-AD8 | aHIV-1 NL-AD8 with IFN | aHIV-1 NL4-3 | aHIV-1 NL4-3 with IFN |
|---|---|---|---|---|---|---|
Parameters obtained from simultaneous fit to full in vitro dataset | ||||||
Rate constant for infection | β | (p24 ng/well·day)−1 | (6.73 ± 2.00) × 10–3 | (8.76 ± 3.74) × 10–3 | ||
Death rate of infected cells | δ | day−1 | 1.56 ± 0.16 | 1.80 ± 0.19 | ||
Production rate of total virus | p | 10–3 × p24 ng/well·(cell·day−1) | 2.55 ± 0.68 | 3.92 ± 1.19 | ||
Antiviral effect of IFN on de novo infection | η | — | No inhibition | 0.47 ± 0.06 | No inhibition | 0.33 ± 0.10 |
Antiviral effect of IFN on virus production | ε | — | No inhibition | 0.06 ± 0.9 | No inhibition | 0.15 ± 0.11 |
Initial amount of virus inoculation | V(0) | p24 ng/well | 0.79 ± 0.57 | 2.03 ± 1.07 | 2.24 ± 1.70 | 1.23 ± 0.29 |
Quantities derived from fitted values | ||||||
Half-life of infected cells | log2/δ | days | 0.45 ± 0.05 | 0.39 ± 0.04 | ||
Viral burst size | (1–ε)p/δ | 10–3 × p24 ng/well·cell−1 | 1.69 ± 0.62 | 1.59 ± 0.65 | 2.14 ± 0.43 | 1.76 ± 0.59 |
Malthusian coefficient | Θ | day−1 | 4.97 ± 0.14 | 2.88 ± 0.09 | 7.24 ± 0.86 | 4.79 ± 0.52 |
Basic reproductive number | R 0 | — | 13.1 ± 0.33 | 6.37 ± 0.43 | 19.0 ± 6.88 | 7.24 ± 0.86 |
