Figure 1 | Scientific Reports

Figure 1

From: Long noncoding RNA expression profiles in gut tissues constitute molecular signatures that reflect the types of microbes

Figure 1

Identification of lncRNAs regulated by commensal microbiota in mice.

(A) Schematic representation of the lncRNA reannotation process. The mouse exon array contained 264 382 probes mapping to 30692 lncRNA transcripts. Probes that overlap with coding genes have been removed. The dataset was based on intestinal epithelium cells of conventionalized mice as compared to germ-free mice. (B) The classification of lncRNAs into five categories (intergenic, intronic, sense, antisense and proximity) according to their relationships with protein-coding genes. The numbers of identified lncRNAs in different categories are shown on the right. (C,D) Pie charts showing the number of microbiota-regulated lncRNAs in each category. When a criteria of fold change>2 and P < 0.05 was accepted, 141 and 148 lncRNAs were respectively up- and down-regulated.

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