Table 1 Summary of proteomic changes in rd10 mice with or without Adalimumab.

From: Adalimumab Reduces Photoreceptor Cell Death in A Mouse Model of Retinal Degeneration

 

Protein

C

rd10

rd10 ADA

OXPHOS

NDUFS3

3.1 ± 0.1

1.5 ± 0.2*

2.4 ± 0.2a

SDHB

2.1 ± 0.1

1.3 ± 0.1*

2.1 ± 0.2a

CORE2

1.4 ± 0.1

0.8 ± 0.1*

1.3 ± 0.1a

COX II

2.0 ± 0.1

0.9 ± 0.1*

2.1 ± 0.2a

Β-F1

1.6 ± 0.1

0.9 ± 0.1*

1.8 ± 0.1a

Glycolysis

GADPH

2.0 ± 0.2

1.2 ± 0.1*

2.1 ± 0.2a

LDHA

0.70 ± 0.02

0.34 ± 0.04*

0.60 ± 0.05a

Pentose phosphate pathway

G6PDH

0.48 ± 0.04

0.36 ± 0.05*

0.64 ± 0.07a

β-oxidation

HADHA

0.34 ± 0.02

0.17 ± 0.01*

0.37 ± 0.03a

Mitochondrial dynamics

OPA1

1.9 ± 0.1

1.0 ± 0.1*

1.8 ± 0.2a

Mitochondrial structure

HSP60

0.13 ± 0.01

0.05 ± 0.01*

0.14 ± 0.01a

  1. Note: Values are expressed as the mean ± SEM of fluorescence intensity (arbitrary units) per ng of total protein of six retinas per group. Values that are significantly different from C57Bl6 (C) are indicated by asterisks *p < 0.05. ‘a’ represent statistical differences (p < 0.05) between rd10 and rd10 ADA (One way ANOVA, Newman-Keuls post-test). ADA: Adalimumab.