Figure 6
From: A Novel Chimeric Anti-PA Neutralizing Antibody for Postexposure Prophylaxis and Treatment of Anthrax
In vivo LeTx neutralization assay in F344 rats.
A. Mean survival time. LeTx and the antibody were simultaneously injected via the tail vein. Group I, 0 μg hmPA6 + 30 μg LeTx; group II, 15 μg hmPA6 + 30 μg LeTx; group III, 30 μg hmPA6 + 30 μg LeTx; group IV, 45 μg hmPA6 + 30 μg LeTx. ***P < 0.001. B. Different concentrations of the antibody were injected and LeTx was injected 5 min later via the tail vein. C. For each rat, 45 μg antibody was injected before (−5 min), after (5 min), or simultaneously (0 min) with LeTx. D. For each rat, 90 μg antibody was injected at different times before LeTx injection. E. Group I, PA (30 μg) was injected 5 min after LF (30 μg) + hmPA6 (45 μg); group II, PA (30 μg) was injected 5 min before LF (30 μg) + hmPA6 (45 μg).
