Figure 6
From: High-resolution NMR characterization of low abundance oligomers of amyloid-β without purification
Simultaneously occurring aggregation pathways of Aβ1-40.
Early aggregates maintain structural similarity to the stable, disordered Aβ1-40 oligomers observed at late aggregation stages. The early aggregates either (i) solely nucleate the disordered oligomers or (ii) act as a single nucleating seed from which the two distinct aggregation pathways bifurcate.
