Table 4 Risk of ESCC associated withBCL-2 rs2279115 C > A genotypes by age, sex, smoking status and drinking status.

From: Functional BCL-2 regulatory genetic variants contribute to susceptibility of esophageal squamous cell carcinoma

 

BCL-2 rs2279115 C>A

BCL-2 rs2279115 C>A

Variable

CC1

CA1

OR2 (95% CI)

P

CC1

AA1

OR2 (95% CI)

P

Sex

 Male

485/380

530/617

0.86(0.71–1.04)

0.123

485/380

159/207

0.70(0.54–0.91)

0.008

 Female

173/130

188/211

0.97(0.66–1.42)

0.868

173/130

52/55

0.74(0.42–1.32)

0.309

Age (year)

 ≤57

327/273

364/412

1.02(0.81–1.30)

0.843

327/273

96/131

0.92(0.65–1.29)

0.619

 >57

331/237

354/416

0.76(0.60–0.96)

0.021

331/237

115/131

0.56(0.40–0.78)

0.001

Smoking status

 No

414/202

341/334

0.70(0.54–0.92)

0.010

414/202

108/109

0.42(0.29–0.59)

0.001

 Yes

352/308

377/494

1.03(0.83–1.28)

0.808

352/308

103/153

1.01(0.81–1.50)

0.532

Drinking status

 No

306/202

341/334

0.78(0.61–0.99)

0.041

306/202

108/109

0.44(0.32–0.62)

0.002

 Yes

352/308

377/494

0.98(0.78–1.23)

0.855

352/308

103/153

1.12(0.80–1.56)

0.514

  1. Abbreviations: ESCC, esophageal squamous cell carcinoma; OR, odds ratio; CI, confidence interval.
  2. 1Number of case patients with genotype/number of control subjects with genotype.
  3. 2Data were calculated by logistic regression, adjusted for sex, age, smoking and drinking status, where it was appropriate.
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