Figure 2
From: Structural insights into the unique inhibitory mechanism of the silkworm protease inhibitor serpin18
Close-up view of RCL.
(A) Comparision of the overallstructure between serpin18 (orange) and human plasminogen activator inhibitor-1 (PDB: 1DB2, blue), (B) human plasminogen activator inhibitor-1 complexed with plasminogen activator (PDB: 3PB1, lightmagenta) and (C) Ovalbumin (PDB: 1OVA, green). All figures were prepared using PyMOL. The reactive center loop of serpin18 and the counterparts of serpins are highlight. (D) Structure-based multialignment of Bombyx mori serpin18 (NP_001139711.1) and 1DB2, Homo sapiens plasminogen activator inhibitor-1 (NP_000593.1; Identity, 18.8%; RMSD, 4.2 Å); 3PB1, Homo sapiens plasminogen activator inhibitor-1 ((NP_000593.1; Identity, 18.6%; RMSD, 4.6 Å ); 1HP7, Homo sapiens alpha-1-antitrypsin (NP_000286.3; Identity, 21.3%; RMSD, 4.5 Å) and 1OVA, Gallus gallus ovalbumin (NP_001073231.1; Identity, 16.9%; RMSD, 4.3 Å). The second structure elements are indicated under the primary sequences and the conserved residues are shaded in blue. The multialignment was generated based on the structural superposition44.
