Figure 6
From: Structural insights into the unique inhibitory mechanism of the silkworm protease inhibitor serpin18
Mode of the reaction of serpin18 with cysteine protease.
I, serpin18 (PDB code: 4R9I); E, cysteine protease (papain, PDB code: 1PPP); EI, Michaelis-like complex (constructed by docking the X-ray structures of serpin18 and papain); EI*, thioacyl-intermediate; E′, degraded protease and I′, degraded serpin18.
