Table 2 Significantly (p < 0.05) altered proteins identified from the trapezius muscle by nLC-MS/MS and MALDI-TOF.

From: Protein alterations in women with chronic widespread pain – An explorative proteomic study of the trapezius muscle

Spot no.

Protein

Ratio CWP vs CON

Type

5538 ƪ

Carbonic anhydrase 3

S&I

6436

Alpha-crystallin B chain

S&I

6530

Carbonic anhydrase 3

S&I

0103

Myosin light chain 1/3, skeletal muscle isoform

C

1425

Myosin light chain 3

C

2733 ƪ

Actin, alpha skeletal muscle

C

4638 ƪ

Troponin T, slow skeletal muscle

C

1831

ATP synthase subunit beta, mitochondrial

M

2742

Creatine Kinase B-type

M

5542

Triosephosphate isomerase

M

6632

Glyceraldehyde-3-phosphate dehydrogenase

M

6751

Pyruvate kinase PKM

M

7451

Adenylate kinase isoenzyme 1

M

7732

Fructose-bisphosphate aldolase A

M

1834

Keratin, type II cytoskeletal 1

S

2852

Desmin

S

3728 ƪ

Ankyrin repeat domain-containing protein 2

S

  1. ↑ = Up-regulated; ↓ = Down-regulated in patients with CWP compared to the CON. The proteins were divided based on UniProt database (http://web.expasy.org) definition on biological process in different groups (labelled Type); S&I = stress and inflammatory, C = contractile, M = metabolic and S = structural proteins. Proteins marked with ƪ were not significant in the OPLS-DA (Table 3).