Table 3 OPLS-DA regression of group membership (CWP vs. CON).

From: Protein alterations in women with chronic widespread pain – An explorative proteomic study of the trapezius muscle

Spot no.

Protein

VIP

CoeffCS

Type

1831

ATP synthase subunit beta, mitochondrial

1.66

+

M

5542

Triosephosphate isomerase

1.65

+

M

2742

Creatine Kinase B-type

1.45

−

M

1829*

Protein disulfide-isomerase

1.27

−

S&I

7732

Fructose-bisphosphate aldolase A

1.21

+

M

1834

Keratin, type II cytoskeletal 1

1.20

+

S

6747*

Fructose-bisphosphate aldolase A

1.18

+

M

7451

Adenylate kinase isoenzyme 1

1.17

−

M

0103

Myosin light chain 1/3, skeletal muscle isoform

1.13

+

C

6436

Alpha-crystallin B chain

1.11

+

S&I

6751

Pyruvate kinase PKM

1.10

+

M

6530

Carbonic anhydrase 3

1.09

+

S&I

2852

Desmin

1.08

−

S

6632

Glyceraldehyde-3-phosphate dehydrogenase

1.05

+

M

4535*

Glutathione S-transferase Mu 2

1.02

−

S&I

1425

Myosin light chain 3

1.01

+

C

3540*

Heat shock protein beta-1

1.00

−

S&I

  1. For each protein is reported CV VIP (VIP >1.0 is significant and only proteins with VIP >1 are shown) and signs of the coefficient (+ or −) (R2 = 0.81, Q2 = 0.65). Proteins with positive coefficients are higher in CWP than in CON and vice versa for negative coefficients. The proteins were divided based on UniProt database (http://web.expasy.org) definition on biological process in different groups (labelled Type); M = metabolic, S&I = stress and inflammatory, S = structural and C = contractile proteins. Proteins marked with *were not significant in the univariate group comparison (Table 2).
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