Figure 6
From: Chromatin states modify network motifs contributing to cell-specific functions
Prioritization of candidate genes by integrating changes of chromatin state and motif architecture.
(A) The workflow based on a chromatin state transition matrix and structure alteration of FFLs for prioritization of candidate genes (see Methods). (B) The enrichment analysis between the top 1% of ranked genes and Cancer Gene Census (CGC) (P-value = 1.3e-05), leukemia-related genes derived from OMIM and KEGG databases (P-value = 7.6e-04). Statistical significance was calculated by hypergeometric test. (C) The GO biological processes enriched by the top 1% of ranked genes (FDR < 0.05). (D) Kaplan-Meier curves of the overall survival for high and low expression of top-ranked gene in 197 AML samples from TCGA. P-value was determined by log-rank test.
