Table 4 Stratified analyses of the C20orf54 rs13042395 polymorphism on cancer risk.

From: Esophageal Squamous Cell Carcinoma and Gastric Cardia Adenocarcinoma Shared Susceptibility Locus in C20orf54: Evidence from Published Studies

 

Heterogeneity test

 

Hypothesis test

 

Comparisons

Q

P

I2(%)

Summary OR (95%CI)

Z

P

Studies

Smoking status

 Smokers

  T vs C

0.95

0.81

0

0.98(0.89,1.08)

0.34

0.73

4

  CT vs CC

11.38

0.01

74

0.90(0.66,1.22)

0.68

0.49

4

  TT vs CC

1.92

0.59

0

1.00(0.79,1.27)

0.02

0.99

4

  CT + TT vs CC

4.79

0.19

37

0.96(0.85,1.08)

0.70

0.48

4

  TT vs CT + CC

5.62

0.13

47

1.06(0.84,1.33)

0.50

0.62

4

 Never smokers

  T vs C

3.47

0.33

13

1.00(0.94,1.06)

0.11

0.91

4

  CT vs CC

0.30

0.96

0

0.95(0.87,1.02)

0.35

0.18

4

  TT vs CC

1.13

0.77

0

0.97(0.84,1.11)

0.44

0.66

4

  CT + TT vs CC

0.52

0.91

0

0.94(0.87,1.02)

1.56

0.12

4

  TT vs CT + CC

14.63

<0.01

79

1.13(0.76,1.67)

0.61

0.54

4

Drinking status

 Drinkers

  T vs C

0.36

0.95

0

0.98(0.88,1.10)

0.27

0.19

4

  CT vs CC

12.86

0.01

77

0.83(0.56,1.22)

0.96

0.34

4

  TT vs CC

0.59

0.90

0

0.99(0.75,1.31)

0.06

0.96

4

  CT + TT vs CC

4.62

0.20

35

0.95(0.82,1.10)

0.65

0.51

4

  TT vs CT + CC

4.75

0.19

37

1.07(0.82,1.40)

0.53

0.60

4

 Never drinkers

  T vs C

1.02

0.80

0

0.96(0.90,1.01)

1.61

0.11

4

  CT vs CC

0.88

0.83

0

0.95(0.88,1.02)

1.38

0.17

4

  TT vs CC

0.67

0.88

0

0.92(0.81,1.05)

1.22

0.22

4

  CT + TT vs CC

1.05

0.79

0

0.94(0.88,1.01)

1.59

0.11

4

  TT vs CT + CC

0.43

0.93

0

0.94(0.83,1.07)

0.87

0.39

4

BMI

 Under weight

  T vs C

0.58

0.75

0

0.87(0.77,0.98)

2.26

0.02

3

  CT vs CC

0.38

0.83

0

0.91(0.77,1.08)

1.06

0.29

3

  TT vs CC

0.66

0.72

0

0.70(0.52,0.93)

2.42

0.02

3

  CT + TT vs CC

1.95

0.38

0

0.89(0.76,1.05)

1.41

0.16

3

  CC vs CT + TT

1.48

0.48

0

0.74(0.56,0.98)

2.07

0.04

3

 Normal weight

  T vs C

0.69

0.71

0

0.85(0.80,0.91)

4.76

<0.01

3

  CT vs CC

3.95

0.14

0

0.82(0.75,0.89)

4.49

<0.01

3

  TT vs CC

0.74

0.69

0

0.76(0.69,0.85)

3.35

<0.01

3

  CT + TT vs CC

1.49

0.47

0

0.81(0.75,0.88)

4.90

<0.01

3

  CC vs CT + TT

0.55

0.76

0

0.93(0.74,1.16)

0.67

0.50

3

Brought forward

 Over weight

  T vs C

2.62

0.27

24

1.03(0.88,1.21)

0.38

0.70

3

  CT vs CC

0.70

0.71

0

1.02(0.82,1.26)

0.19

0.85

3

  TT vs CC

3.46

0.18

42

1.06(0.73,1.54)

0.31

0.76

3

  CT + TT vs CC

1.17

0.56

0

1.04(0.85,127)

0.37

0.71

3

  CC vs CT + TT

5.54

0.06

64

1.08(0.76,1.54)

0.45

0.66

3

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