Figure 1 | Scientific Reports

Figure 1

From: Identification of a multi-cancer gene expression biomarker for cancer clinical outcomes using a network-based algorithm

Figure 1

Schematic representation of the network clinical association algorithm (NCA).

Starting from a single seed gene (black), the first cycle generates modules that include the seed gene and each of the connected genes (blue). The 6 modules of 2 genes are then evaluated by their goodness of fit in a Cox survival model. Only those grown modules that improve (filled blue circles) the evaluation are considered for the next grow cycle. Only a proportion of the best improved modules are further explored in the next cycle (represented by a percentage of the distribution of all modules, shown in green, evaluated in the 4th cycle). This procedure continues until no improvement is observed. The NCA algorithm was run for each cancer type and for all cancer datasets (multi-NCA).

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