Table 1 Morphometric and metabolic parameters.

	9-wk	11-wk	13-wk	15-wk	17-wk
Body weight, g
wildtype mice	22.59 ± 0.35	19.91 ± 0.28	20.35 ± 0.31	20.88 ± 0.32	22.21 ± 0.34
db/db mice	41.14 ± 0.96^**	40.34 ± 1.09^**	42.35 ± 1.14^**	45.36 ± 1.24^**	50.85 ± 0.96^**
Serum glucose, mmol/L
wildtype mice	6.31 ± 0.35	4.92 ± 0.33	5.20 ± 0.34	6.56 ± 0.89	4.93 ± 0.11
db/db mice	17.08 ± 0.88^**	20.72 ± 2.15^**	17.33 ± 1.00^**	12.94 ± 0.83^**	10.49 ± 0.35^**
CRE, mg/dL
wildtype mice	10.52 ± 0.48	14.51 ± 1.57	14.35 ± 1.81	16.95 ± 1.89	19.14 ± 2.33
db/db mice	6.02 ± 0.81^**	4.68 ± 0.55^**	4.50 ± 0.53^**	3.80 ± 0.64^**	3.48 ± 0.71^**
UACR, mg/mmol
wildtype mice	56.57 ± 5.92	83.77 ± 12.15	77.82 ± 10.86	65.76 ± 5.93	65.13 ± 8.95
db/db mice	95.47 ± 6.50^**	135.00 ± 18.57^*	131.37 ± 18.57^*	138.28 ± 19.68^**	153.62 ± 27.06^*

Values are expressed as mean ± SE; Keys: CRE, urine creatinine; UACR, urinary albumin to creatinine ratio; ^*P < 0.05, ^**P < 0.01 compared with age-matched wildtype mice.

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