Figure 7 | Scientific Reports

Figure 7

From: Promoter-level expression clustering identifies time development of transcriptional regulatory cascades initiated by ErbB receptors in breast cancer cells

Figure 7

(a) FOSL1 regulation by FOS in HRG-induced MCF-7 cells. cFOS expression (red curve) and protein abundance (dark gray region) rapidly increase after HRG-induction. Consistently, FOSL1 expression (orange curve) increases in the 45–120 min time span, and decreases as FOS protein abundance decreases. FOSL1 protein level, instead, is sustained up to 8 hrs. (b) DUSP5/DUSP10 regulation by AP-1 complex. DUSP5/10 expression (green curves) increases in the 45–120 min time span and decreases as FOS protein abundance decreases. (c) RARA regulation by AP-1 complex. RARA expression (blue curve) increases peaks in the 100–180 min time interval and slowly decreases at late time-points.

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