Table 1 Panel of regulatory interactions inferred by CIDER for the MCF-7 HRG and EGF time-courses.

From: Promoter-level expression clustering identifies time development of transcriptional regulatory cascades initiated by ErbB receptors in breast cancer cells

Regulatory interaction

Novel in MCF-7

Validated in

MCF-7

other tissues

SRF -> FOS

 

2

16–22

SRF -> DUSP1

x

 

16

SRF -> DUSP2

x

 

16

SRF -> EGR1

 

55

16–22

SRF -> EGR2

x

 

16–22

SRF -> EGR4

x

 

16

SRF -> NR4A1

x

 

16

FOS -> FOSL1

 

36, 37

38, 39

AP1 -> DUSP5

 

36

 

AP1 -> DUSP10

x

  

AP1 -> RARA

 

56

 

FOXO3 -> DUSP5

x

 

45–47

FOXO3 -> DUSP10

x

 

44

IRF1 -> RARA

x

  
  1. The interactions in bold are present in both the MCF-7 EGF and HRG time-courses. Each interaction is annotated with the references to the literature experimentally supporting the existence of the interaction in the MCF-7 time-course and/or in other tissues.
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