Figure 3
From: MitoRCA-seq reveals unbalanced cytocine to thymine transition in Polg mutant mice
Comparison of the mutation load between wild-type and Polg mutant mice.
(A) The number of mutation sites reliably detected in individual samples. (B) For each comparison, mtDNA mutations that are shared between a pair of wild-type and Polg mutant littermates in the given tissue were first identified. WT1 is the littermate control of Mut1 and both mice were generated from the same cross of heterozygous Polg mice. WT2 and Mut2 are littermates and served as biological replicates. The overall frequency of these shared mutations was then compared in the corresponding sample pairs (KS test).
