Figure 6
From: MitoRCA-seq reveals unbalanced cytocine to thymine transition in Polg mutant mice
The strand asymmetry of C → T transitions in Polg mutant mice.
For mutation identification mitoRCA-seq reads were mapped to the L-strand of the reference mouse mitochondrial genome. The resulting mutations were subdivided into all possible 12 categories and the percentages of mutations detected in each reciprocal pair (e.g., C → T and G → A) are plotted side-by-side horizontally. In both Polg mutant mice C → T transitions are much higher than G → A transitions (or C → T transitions on the H strand), indicating stand asymmetry of C → T transitions in the mutator mice.
