Table 2 Results from top genetic variants associated with post-operative pulmonary complications.
Discovery Population | Replication Population | Pooled Population | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
Gene | SNP | bModel | OR (unadjusted) | P-value | aOR | P-value | aOR | P-value | aOR | P-value |
TRAF2 | rs6560652 | dom | 4.10 (1.97–8.51) | 0.00015 | 4.65 (2.03–10.68) | 0.00029 | 1.34 (0.71–2.53) | 0.37 | 2.25 (1.38–3.66) | 0.0011 |
MAP2K4 | rs12452497 | add | 0.64 (0.41–1.00) | 0.050 | 0.57 (0.35–0.92 | 0.023 | 0.63 (0.41–0.98) | 0.039 | 0.60 (0.43–0.83) | 0.0018 |
MAP3K5 | rs9389421 | dom | 1.70 (0.98–2.94) | 0.058 | 2.00 (1.08–3.72) | 0.028 | 1.76 (0.97–3.19) | 0.063 | 1.92 (1.25–2.93) | 0.0027 |
MAP3K5 | rs13195420 | dom | 0.60 (0.35–1.00) | 0.051 | 0.52 (0.29–0.91) | 0.023 | 0.58 (0.33–1.01) | 0.055 | 0.55 (0.37–0.81) | 0.0029 |
MAP3K5 | rs13193586 | dom | 1.73 (0.82–3.65) | 0.15 | 2.49 (1.08–5.75) | 0.033 | 2.04 (0.78–5.30) | 0.14 | 2.24 (1.20–4.18) | 0.011 |
MAP3K5 | rs13203080 | rec | 3.90 (1.14–13.34) | 0.030 | 4.86 (1.14–20.74) | 0.033 | n/a | n/a | 5.38 (1.33–21.72) | 0.018 |
TNF | rs1800629 | dom | 2.10 (1.18–3.44) | 0.011 | 2.46 (1.35–4.46) | 0.0032 | 1.00 (0.55–1.82) | 0.99 | 1.55 (1.02–2.34) | 0.039 |
DAXX | rs3130100 | dom | 1.34 (0.77–2.35) | 0.31 | 1.90 (1.01–3.57) | 0.047 | 1.11 (0.61–2.02) | 0.74 | 1.42 (0.93–2.18) | 0.11 |
MAP2K4 | rs7207011 | dom | 2.93 (1.01–8.50) | 0.048 | 3.63 (1.11–11.82) | 0.032 | 0.95 (0.35–2.54) | 0.91 | 1.70 (0.82–3.50) | 0.15 |
TNFRSF1B | rs17037696 | dom | 1.67 (1.00–2.79) | 0.052 | 1.76 (1.01–3.08) | 0.048 | 0.77 (0.44–1.32) | 0.34 | 1.12 (0.76–1.65) | 0.56 |
TRAF2 | rs7019752 | dom | 2.06 (1.11–3.80) | 0.021 | 2.17 (1.09–4.33) | 0.028 | 0.55 (0.28–1.07) | 0.076 | 1.04 (0.66–1.65) | 0.86 |
