Table 4 Higher-order gene-gene interactions among TNF/TRAF2/ASK1/p38 kinase signaling pathway variants modulating lung complications risk.

From: Genetic variation in the TNF/TRAF2/ASK1/p38 kinase signaling pathway as markers for postoperative pulmonary complications in lung cancer patients

Nodes

Event, N(%)

No Event, N(%)

aOR(95%CI)

P-value

1 and 2

39(24.22%)

122(75.78%)

1(reference)

0.066

3

59(35.33%)

108(64.67%)

1.63(0.97–2.75)

4 and 5

97(51.32%)

92(48.68%)

3.88(2.34–6.43)

1.47 × 10−7

P for trend

7.63 × 10−8

  1. aAdjusted for age at surgery, gender, intra-operative transfusion, % DLCO predicted and chest wall resection.
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