Table 2 Correlation between gene expression of pro-metastatic ligand and receptor pairs.

From: Analysis of gene expression of secreted factors associated with breast cancer metastases in breast cancer subtypes

Ligand

Receptor

TCGA

METABRIC

R

p-value

R

p-value

IL6

GP130 (IL6ST)

−0.18

3 × 10–6

−0.20

3 × 10−9

CSF2 (GMCSF)

GMRA (CSF2RA)

0.34

<2 × 10−16

0.23

8 × 10−12

GMRB (CSF2RB)

0.42

<2 × 10−16

0.12

4 × 10−4

CCL5

CCR5

0.86

<2 × 10−16

  

VEGFA

VEGFR2 (KDR)

0.11

6 × 10−3

  

NRP1

0.06

0.13

  

VEGFC

VEGFR3 (FLT4)

0.49

<2 × 10−16

0.05

0.1

NRP2

0.42

<2 × 10−16

0.16

3 × 10−6

  1. Spearman correlation coefficient (R) and corresponding p-value for mRNA expression of a ligand with its associated receptor(s) (Fig. 1) from RNA sequencing data from primary breast tumors in TCGA and microarray gene expression data from primary tumors in METABRIC. Gene names are consistent with Fig. 1, with aliases used in TCGA or METABRIC in parentheses.
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