Table 3 Clinical features of patients in different groups (EBER cut-off: 20%).

From: Epstein-Barr virus positive diffuse large B-cell lymphoma predict poor outcome, regardless of the age

Variable

Number. (%)

All age

P value

Elderly group

P value

Young group

P value

EBV+

EBV−

EBV+

EBV−

EBV+

EBV−

Number. (%)

Number. (%)

Number. (%)

CRP

117

20

97

 

14

62

 

6

35

 

Over ULN

57 (48.7)

15 (75.0)

42 (43.3)

0.010

10 (71.4)

28 (45.2)

0.076

5 (83.3)

14 (40.0)

0.080

Normal

60 (51.3)

5 (25.0)

55 (56.7)

 

4 (28.6)

34 (54.8)

 

1 (16.7)

21 (60.0)

 

β2MG

134

22

109

 

14

72

 

8

40

 

Over ULN

59 (44.0)

16 ()

43 (72.7)

0.003

10 (71.4)

33 (45.8)

0.080

6 (75.0)

10 (25.0)

0.012

Normal

75 (56.0)

6 ()

69 (27.3)

 

4 (28.6)

39 (54.2)

 

2 (25.0)

30 (75.0)

 

TK1

92

15

77

 

9

52

 

6

25

 

Over ULN

28 (30.4)

4 (26.7)

24 (31.2)

1.000

2 (22.2)

15 (28.8)

1.000

2 (33.3)

9 (36.0)

1.000

Normal

64 (69.6)

11 (73.3)

53 (68.8)

 

7 (77.8)

37 (71.2)

 

4 (66.7)

16 (64.0)

 

CA125

108

18

90

 

13

58

 

5

32

 

Over ULN

42 (38.9)

13 (72.2)

29 (32.2)

0.001

8 (61.5)

17 (29.3)

0.051

5 (100.0)

12 (37.5)

0.014

Normal

66 (61.1)

5 (27.8)

61 (67.8)

 

5 (38.5)

41 (70.7)

 

0 (0.0)

20 (62.5)

 

ESR

163

22

141

 

14

88

 

8

53

 

Over ULN

49 (30.1)

19 (86.4)

30 (21.3)

<0.001

13 (92.9)

20 (22.7)

<0.001

6 (75.0)

10 (18.9)

0.003

Normal

114 (69.9)

3 (13.6)

111 (78.7)

 

1 (7.1)

68 (77.3)

 

2 (25.0)

43 (81.1)

 

Ferritin

152

24

128

 

18

82

 

6

46

 

Over ULN

52 (34.2)

15 (62.5)

37 (28.9)

0.001

10 (55.6)

24 (29.3)

0.033

5 (83.3)

13 (28.3)

0.015

Normal

100 (65.8)

9 (37.5)

91 (71.1)

 

8 (44.4)

58 (70.7)

 

1 (16.7)

33 (71.7)

 

LDH

250

34

216

 

24

139

 

10

77

 

Over ULN

114 (45.6)

20 (58.8)

94 (43.5)

0.096

15 (62.5)

59 (42.4)

0.068

5 (50.0)

35 (45.5)

1.000

Normal

136 (54.4)

14 (41.2)

122 (56.5)

 

9 (37.5)

80 (57.6)

 

5 (50.0)

42 (54.5)

 

CK

149

24

125

 

16

70

 

8

55

 

Complex

5 (3.4)

1 (4.2)

4 (3.2)

0.590

1 (6.2)

2 (2.9)

0.465

0 (0.0)

2 (3.6)

1.000

Normal

144 (96.6)

23 (95.8)

121 (96.8)

 

15 (93.8)

68 (97.1)

 

8 (100.0)

53 (96.4)

 

BM

150

25

125

 

17

81

 

8

44

 

Positive

17 (11.3)

4 (16.0)

13 (10.4)

0.487

3 (17.6)

8 (9.9)

0.398

1 (12.5)

5 (11.4)

1.000

Negative

133 (88.7)

21 (84.0)

112 (89.6)

 

14 (82.4)

73 (90.1)

 

7 (87.5)

39 (88.6)

 
  1. Abbreviations: EBV: Epstein-Barr virus; CRP: serum C reactive protein; ULN: upper limit of normal; β2MG: β2 microglobulin; ESR: erythrocyte sedimentation rate; LDH: lactate dehydrogenase; CK: chromosome karyotype; BM: bone marrow.